Playbooks

2-4 Load is a defensive set inside the Nickel formation, and the play list makes that obvious: every call here is a coverage shell or a pressure package, not a route concept. The alignment puts two down defensive tackles on the interior with four linebacker types standing up across the front, backed by five defensive backs including the nickel corner. The RDT and SUBLB tags tell you the game is substituting a defensive tackle out and a linebacker in, so you are fielding a lighter, faster front seven than a base 4-2-5 Nickel look. That substitution is the entire point of the set: you trade one interior anchor for a hybrid edge or coverage linebacker who can rush, drop into a seam hook, or match a tight end down the field.
Play this on second and long or third and medium, where the offense is likely in three or four wide and your lighter SUBLB front is not exposed to a downhill run game.
Rotate shells behind an identical front: run Cover 3 Sky, then Cover 4 Palms, then Cover 6 Willie from the same look so the QB cannot pre-snap diagnose the deep rotation.
User the free safety or the sub linebacker rather than the nickel corner, since the seam hook and middle of the field are where this set is most vulnerable when you blitz.
Use Double Bracket or 1 Double Wr1 against an offense that funnels everything to one receiver, and pair it with a hard flat pre-snap adjustment to squeeze the checkdown.
Mix the Cross Games calls sparingly and against passing downs only, because the pressure comes at the cost of run integrity and the offense will check to a run if it reads your front.
Manually adjust your defensive line to pinch or slant inside when you suspect a run, which partially offsets the missing defensive tackle in the RDT substitution.