Playbooks

Split Pro Offset Wk puts you in 21 personnel out of Shotgun with both backs flanking the quarterback in a split alignment, offset weak to create a numbers advantage on the backside. Unlike the standard Split Pro sets that keep the backfield balanced, the weak offset immediately declares run strength away from the tight end, which forces the defense to either overload the strong side and concede the pull path, or stay balanced and lose a body at the point of attack. Your receiver alignment is condensed: two wideouts and a tight end, meaning you are almost never in a spread look, and the passing concepts are built off run action rather than raw route volume.
The 3DRB tag matters here because it lets you put a receiving back in the slot equivalent role out of the backfield, and the Gadget tag opens up misdirection looks that most opponents will not have rep'd against. Slot Cross and X Dig are your primary intermediate attacks, both of which put a receiver on a horizontal or 15 yard in breaking stem that punishes Cover 3 buzz and any zone shell with a soft hook defender. HB Power O and Read Option give you the downhill and option run game from the same shell, which is where the set earns its money: the defense cannot commit to the run fit without vacating the dig window, and it cannot sit in a two high shell without giving up a numbers advantage to the offset side.
The matchup isolation comes from the second back. When you motion or hot route the offset back out of the backfield, most defenses will check him with a linebacker or a strong safety, which is a coverage speed mismatch you can attack on PA F Slide or HB Slip Screen. Against man coverage, that back release is your cleanest man beater in the set because the defender assigned to him has to work through traffic created by the tight end and the pulling guard action.
Check the safety rotation pre-snap: if you see two high, run HB Power O to the offset weak side because the box is light and the pull gets a clean angle. If you see single high with a rotated strong safety, throw X Dig into the vacated middle.
Motion the offset back across the formation to identify man versus zone, then send him on a hot route flat or streak depending on the answer, since a linebacker chasing him is your best matchup in the set.
Use HB Slip Screen on second and medium after you have established Power O, especially when the opponent starts sending A gap pressure. The screen turns their aggression into free yards.
Save PA F Slide for third and 6 to 9 in the red zone approach area, where man coverage rates spike and the back release beats a linebacker cleanly.
Hot route the tight end to a corner or seat route when facing Cover 3 buzz to give Slot Cross a high low complement, otherwise the concept can stall against a disciplined hook defender.